Nhamba yeCas: 54-31-9 Molecular Formula:C12H11ClN2O5S
| Melting Point | 261-263°C |
| Density | 1.16 (yakashata fungidziro) |
| kuchengetedza temp | Mamiriro ekunze akadzikama, Tembiricha yemumba 2-8°C |
| solubility | DMSO:> 5 mg/mL pa60 °C |
| optical chiitiko | N/A |
| Chitarisiko | Off-White Solid |
| Kuchena | ≥98% |
Telmisartan yakatangwa muUS kurapa hypertension.Inogona kugadzirirwa mumatanho masere kutanga nemethyl 4-amino-3-methyl benzoate;yekutanga uye yechipiri cyclization mubenzimidazole mhete inoitika pamatanho 4 uye 6 zvakateerana.Telmisartan inovhara kuita kweangiotensin II (Ang II), iyo yekutanga effector molecule ye renin-angiotensin-aldosterone system (RAAS).Ndiyo yechitanhatu yekirasi iyi ye 《sartans》 kutengeswa mushure meiyo inotungamira musanganiswa Losartan.Mhedzisiro yayo inogara kwenguva refu (24h hafu yeupenyu) inogona kunge iri mutsauko mukuru nevamwe vapikisi veangiotensin II.Kusiyana nemamwe maajenti akati wandei ari muchikamu ichi, chiitiko chayo hachitsamiri pakushandurwa kuita metabolite inoshanda, iyo 1-O-acylglucuronide iri iyo yakakosha metabolite inowanikwa muvanhu.Telmisartan mupikisi ane simba anokwikwidza weAT1 receptors anopindirana mazhinji akakosha mhedzisiro yeangiotensin II asi ichishayikwa hukama hweAT2 subtypes kana mamwe mareceptor anobatanidzwa mukuronga kwemoyo.Mune akati wandei zvidzidzo zvekiriniki, Telmisartan, panguva imwe chete zuva nezuva, yakagadzira inoshanda uye yakaramba iripo yekudzikisa kuderera kweropa ine yakaderera chiitiko chemhedzisiro (kunyanya kukosora kwakabatana neACE inhibitors muvarwere vakura).
Telmisartan inopikisa angiotensin II receptor.
