Nhamba yeCas: 146-56-5 Molecular Formula: C20H21ClN2O4
| Melting Point | 176-178°C |
| Density | 1.02 g/cm³ |
| kuchengetedza temp | yakabvarurwa patembiricha yemumba, kunze kwezuva rakananga uye munzvimbo ine mwando |
| solubility | 50 mg/ml (Mune ethanol);Insoluble mumvura |
| optical chiitiko | +111.6 madhigirii (C=1, methanol) |
| Chitarisiko | chena kana inenge yakachena crystalline powder |
| Kuchena | ≥97% |
i "dihydropyridine calcium antagonist" (calcium antagonist, kana slow channel blocker) iyo inodzivisa kufamba kwe "calcium ions" kune vascular smooth muscle cells uye cardiac myocytes.Data yekuedza inoratidza kuti inosanganiswa ne "nzvimbo dzinosunga" dze "dihydropyridines" uye "non-dihydropyridines".Zvese zviri zviviri zvemoyo nevascular smooth tsandanyama 'contractile process' zvinoenderana nekupinda kwe'extracellular calcium ions' mumaseru aya kuburikidza nechani chaimo.inosarudza inodzivisa kuyerera kwe calcium ions kuyambuka aya maseru membranes, nzira inokanganisa vascular smooth muscle masero kupfuura masero emwoyo.A negative inotropic (Inotrope) effect, kana kuderedzwa kwemyocardial contractility, inogona kuonekwa in vitro.Zvisinei, migumisiro yakadaro haina kuonekwa mumhuka inotungamirirwa mukati memushonga wakatemerwa wekurapa.Serum calcium concentrations haina kukanganiswa ne.Muhutano pH range, ionised compound (pKa = 8.6) iyo kushamwaridzana kwayo ne calcium channel receptors inoratidzwa nekufambira mberi kwe receptor inosunga saiti conjugation uye dissociation, uye iyi inofambira mberi chiyero chemaitiro inoguma mukufambira mberi.
inonzi peripheral arterial vasodilator inoshanda zvakananga pavascular smooth muscle, zvichiita kuti kuderedzwa kweperipheral vascular resistance uye kuderera kweropa.Iyo chaiyo nzira iyo inobvisa angina haina kunyatsonzwisiswa, asi inofungidzirwa kuti inosanganisira zvinotevera: Exertional angina: Muvarwere vane exertional angina, NORVASC inoderedza zvachose peripheral resistance (afterload) panguva yebasa remwoyo chero ipi zvayo yekurovedza muviri uye inoderedza chiyero. pressure chigadzirwa, nokudaro kuderedza myocardial oxygen kudiwa.
Pakutanga 5mg kamwe chete zuva nezuva, ichiwedzera kusvika pakukwirira kwe10mg kamwe pazuva.
