Cetilistat Cas nhamba: 282526-98-1 Molecular Formula:C25H39NO3

Tsanangudzo Pfupi:

Cas nhamba: 282526-98-1

Kemikari Zita: Cetilistat

Molecular Formula:C25H39NO3

Anoreva zvakafanana:cetilistat Cetilistat(Alt-962) Cetilstat 2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one

Tumira email kwatiri

Product Detail

Product Tags

products specification

Melting Point	72.0 kusvika 76.0 °C
Density	1.02
kuchengetedza temp	Yakavharwa pakaoma, 2-8°C
solubility	Chloroform (Zvishoma), Ethyl Acetate (Zvishoma)
optical chiitiko	N/A
Chitarisiko	Off-white Cryst
Kuchena	≥98%

pharmacodynamics

Cetilistat (inozivikanwawo seATL-962) yakabvumidzwa munaGunyana 2013 neJapan Ministry of Health, Labor and Welfare yekurapa kufutisa, yakaganhurirwa kune varwere vane ese ari maviri emhando 2 chirwere cheshuga mellitus (T2DM) uye dyslipidemia, uye ine huwandu hwemuviri. index (BMI)25 kg/m²pasinei nekurapa kwekudya uye / kana kurovedza muviri.Sezvinoita orlistat, cetilistat inoshanda kuburikidza nekudzivirirwa kwepancreatic lipases mumatumbo kuti inhibisa kunyura kwemafuta uye nekudaro kuderedza caloric kutora kubva mukudya.Chirongwa chemakemikari yekurapa hachina kutsanangurwa muzvinyorwa zvesainzi, asi patent inotsanangura cetilistat inotsanangurawo kuumbwa kwemaanalogi ane akasiyana aryl anotsiva uye lipophilic miswe.Kugadzirwa kwecetilistat kunosanganisira kuderedzwa kwehexadecylcarbonochloridate ne 2-amino-5-methylbenzoic acid;mamwe analogis akagadzirwa nekusiyana kwecarbonochloridate uye 2-aminobenzoic acid zvikamu.Cetilistat inhibitor yakasimba yevanhu uye rat pancreatic lipase ine IC_50sye15 uye 136 nM, zvichiteerana, ine zvishoma inhibition yetrypsin kana chymotrypsin.