Nhamba yeCas: 224785-91-5 Molecular Formula:C23H33ClN6O4S
| Melting Point | 214-216°C |
| Density | N/A |
| kuchengetedza temp | Mamiriro ekunze, 2-8°C |
| solubility | N/A |
| optical chiitiko | N/A |
| Chitarisiko | Ichena kune Off-White Cyrstalline |
| Kuchena | ≥98% |
aiva mumiririri wechipiri kuti atengeswe uye ane mukana wekuti nguva yake yekutanga haina kuderedzwa nekutora mishonga padumbu rakazara .Iine 30 nguva yakawanda se inhibitor yePDE5 (inoreva IC50, 3.9 nM) kupfuura sildenafil uye 10 nguva yakawanda kupfuura tadalafil, ine sarudzo huru (> 1,000 times) yePDE5 yevanhu pane PDE2, PDE3, uye PDE4 uye kusarudzwa kuri pakati nepakati (>80 nguva) yePDE1.Iyo PDE inhibitory selectivity uye zvese zviri zviviri in vitro uye in vivo potency yeiyo itsva PDE5 inhibitor.yakanyatso kuvharira hydrolysis yecGMP nePDE5, ine IC50 ye0.7 nM (sildenafil 6.6 nM).Iyo IC50 yePDE1 yaive 180 nM, yePDE6 11 nM, uye yePDE2, PDE3 uye PDE4 inodarika 1,000 nM.
Inosarudza phsphodiesterase type 5 (PDE5) inhibitor
Chiremba zano rekushandisa
