Cas nhamba: 1115-70-4 Molecular Formula: C4H11N5
| Melting Point | 233-236 ℃ |
| Density | 1.48 g/cm³ |
| kuchengetedza temp | 15-30 ℃ |
| solubility | Soluble mumvura, soluble mu ethanol, uye isinganyunguriki mu chloroform ne benzene. |
| optical chiitiko | +25.7 madhigirii (C=1, mvura) |
| Chitarisiko | white crystalline powder |
Iyo molecular pharmacological mechanism ye parizvino haina kunyatsonzwisiswa.Zvinozivikanwa kuti inoshanda zvishoma pachiropa, ichideredza gluconeogenesis (kureva kugadzirwa kweglucose) uye kuderedza insulin kuramba.Zvimwe zvidzidzo zvakaratidza kuti zvinogona kushandura AMP activated protein kinase (AMPK), inova imwe yenzira dzinokosha dzekudzivisa chiropa gluconeogenesis uye kunatsiridza insulin senitivity muinsulin sign transduction nzira.AMPK, seprotein kinase, inobata basa rinokosha kwete chete mu insulini yechiratidzo nzira, asiwo muhuwandu hwemagetsi uye glucose uye mafuta metabolism.Kuedza kwemhuka uye zvidzidzo zvekiriniki zvakaratidza izvo zvinogona kukonzera shanduko huru mukuumbwa kwefecal microbiota muchirwere cheshuga, izvo zvinogona kwete kungobatsira pakuvanzika uye kuita kweglucagon senge peptide-1 (GLP-1), asi zvakare kuratidza kuvandudza insulin senitivity. , inovawo imwe yenzira dzakakosha dzeayo anti type 2 chirwere cheshuga.
Ichi chigadzirwa chinofanira kushandiswa mune zviduku zvishoma uye zvishoma nezvishoma kuwedzera maererano nemamiriro emurwere.Nhamba yekutanga yechigadzirwa ichi (hydrochloride mapiritsi) inowanzoita 0.5 gramu, kaviri pazuva;Kana 0.85 magiramu, kamwe chete pazuva;Tora nekudya.
Ichi chigadzirwa chinofanira kushandiswa mune zviduku zvishoma uye zvishoma nezvishoma kuwedzera maererano nemamiriro emurwere.Nhamba yekutanga yechigadzirwa ichi (hydrochloride mapiritsi) inowanzoita 0.5 gramu, kaviri pazuva;Kana 0.85 magiramu, kamwe chete pazuva;Tora nekudya.
