l Cas nhamba: 171596-29-5 Molecular Formula: C₂₂H₁₉N₃O₄
| Melting Point | >193°C |
| Density | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| kuchengetedza temp | -20°C |
| solubility | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg/ml |
| optical chiitiko | [α]/D +68 kusvika +78°, c = 1 muchloroform-d |
| Chitarisiko | Ichena kusvika Kuchena-Ichena Solid |
| Kuchena | ≥98% |
(zita remusika kana) rudzi rwePDE5 inhibitor inoshandiswa kurapa erectile dysfunction, benign prostatic hypertrophy uye pulmonary arterial hypertension.Mhedzisiro yekuzorodza mitsipa yeropa uye kuwedzera kuyerera kweropa mu corpus cavernosum.Iyo mashandiro ekuita ndeye kuvharidzira chiitiko che cGMP chaiyo phosphodiesterase type 5 (PDE5).PDE5 inosvibisa cGMP mune corpus cavernosum iri pedyo nepeni.Naizvozvo, tadalafi inotungamira kune yakawedzera kuwanda kwecGMP iyo inowedzera kukonzera yakatsetseka tsandanyama kuzorora uye kuwedzera kweropa kuyerera mu corpus cavernosum.Zvimwe zvidzidzo zvekiriniki zvakaratidzawo kuti zvinogona kuvandudza endothelia basa muvarume vane njodzi yakawedzera yemoyo uye kuderedza zviratidzo zveweti yechipiri kune benign prostatic hyperplasia.
analgesic, uptake blocker, mu-opiod receptor agonist.A phosphodiesterase 5 inhibitor.inoshandiswa kurapa erectile dysfunction.
yakasiyana nekugadzirwa kubva kune zvose sildenafil uye vardenafil.Inokurumidza kubatwa uye inokwira muhutano (378 μg / L mushure me 20-mg dose) mushure memaawa maviri, ichiratidza hafu yakareba yehupenyu hwemaawa 17.5.Iyo zvakare inogadziriswa nechiropa (CYP3A4).Zvinonyanya kukosha, iyo pharmacokinetics haina kukanganiswa nedoro kana kudya kwekudya kana nezvinhu zvakaita seshuga kana kusagadzikana kwehepatic kana renal basa.
