Nhamba yeCas: 147403-03-0 Molecular Formula: C24H29N5O3
| Melting Point | 230°C |
| Density | 1.41g/cm³ |
| kuchengetedza temp | 2-8℃ |
| solubility | Inenge isinganyungudike mumvura, uye solubility mu ethanol i 5.5 mg/m. |
| optical chiitiko | +76.5 madhigirii (C=1, ethanol) |
| Chitarisiko | chena kana chena-chena yakasimba, isinganhuhwi |
isiri peptide, inobata nemuromo angiotensin II (AT) receptor antagonist.Iyo ine high selectivity yakanangana nemhando I receptor (AT1) uye inogona kukwikwidzana pasina chero zvinokurudzira.Inogonawo kurambidza AT1 receptor mediated aldosterol kuburitswa kubva kuadrenal glomerular masero, asi haina inhibitory mhedzisiro pakuburitswa kwe potassium, zvichiratidza maitiro ayo ekusarudza paAT1 receptors.In vivo kuyedza pamhando dzakasiyana dze hypertension mhuka mhando dzakaratidza kuti ine yakanaka antihypertensive mhedzisiro uye haina yakakosha kukanganisa kwemoyo contractile basa uye kurova kwemoyo.Hapana antihypertensive effect pamhuka dzine normal blood pressure
Antihypertensive mishonga.iAngiotensin II (Ang II) inopikisa inodzivirira iyo inovharira kusungwa kweAng II kune AT1 receptors (yayo chaiyo inopikisa mhedzisiro paAT1 receptors ingangoita 20000 nguva yakakura kupfuura iyo yeAT2), nokudaro ichivharira vascular contraction uye aldosterone kusunungurwa, zvichikonzera hypotensive effect
Iyo yakakurudzirwa yekutanga dose yemapiritsi ndeye 80mg (2 mapiritsi), inotorwa nemuromo kamwe pazuva.Kazhinji, kana isingashande kwemavhiki e4, iyo dosage inogona kuwedzerwa kusvika 160mg (4 mahwendefa) kamwe pazuva.Zvinoenderana nedata rekushandisa kwekiriniki yekune dzimwe nyika, iyo yakanyanya dose inogona kusvika 320mg (8 mahwendefa) kamwe pazuva
1.Varwere vane hypertension yakaoma nechirwere cheshuga, hypertension yakaoma nenephropathy kana nyore chirwere cheshuga nephropathy,
2.varwere vane hypertension yakaoma nemoyo kukundikana kana myocardial infarction
