Cas nhamba: 144701-48-4 Molecular Formula:C33H30N4O2 Featured Image

Nhamba yeCas: 144701-48-4 Molecular Formula:C33H30N4O2

Tsanangudzo Pfupi:

Cas nhamba: 144701-48-4
Kemikari Zita:
Molecular Formula:C33H30N4O2

Anoreva zvakafanana:MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277;PRITOR;BIBR 277;misartan;BIBR 277SE

Tumira email kwatiri

Product Detail

Product Tags

Products Specification

Melting Point	261-263°C
Density	1.16 (yakashata fungidziro)
kuchengetedza temp	Mamiriro ekunze akadzikama, Tembiricha yemumba 2-8°C
solubility	DMSO:> 5 mg/mL pa60 °C
optical chiitiko	N/A
Chitarisiko	Off-White Solid
Kuchena	≥98%

Tsanangudzo

yakatangwa muUS kurapa hypertension.Inogona kugadzirirwa mumatanho masere kutanga nemethyl 4-amino-3-methyl benzoate;yekutanga uye yechipiri cyclization mubenzimidazole mhete inoitika pamatanho 4 uye 6 zvakateerana.inovhara kuita kweangiotensin II (Ang II), iyo yekutanga effector molecule ye renin-angiotensin-aldosterone system (RAAS).Ndiyo yechitanhatu yekirasi iyi ye 《sartans》 kutengeswa mushure meiyo inotungamira musanganiswa Losartan.Mhedzisiro yayo inogara kwenguva refu (24h hafu yeupenyu) inogona kunge iri mutsauko mukuru nevamwe vapikisi veangiotensin II.Kusiyana nevamwe vamiririri vakati wandei vari muchikamu ichi, chiitiko chayo hachitsamiri pakushandurwa kuita metabolite inoshanda, iyo 1-O-acylglucuronide iri iyo huru metabolite inowanikwa muvanhu.ndiye ane simba anokwikwidza anopikisa weAT1 receptors anopindirana mazhinji akakosha mhedzisiro angiotensin II ichiri kushaya hukama kune iyo AT2 subtypes kana mamwe ma receptors anobatanidzwa mumutemo wemoyo.Muzvidzidzo zvekiriniki zvakati wandei, kamwe chete zuva rega rega, zvakaburitsa zvinobudirira uye zvakatsiga zvekudzivirira kweropa-kuderedza mhedzisiro ine yakaderera chiitiko chemhedzisiro (kunyanya chikosoro chine chekuita nekurapa kwakabatana neACE inhibitors muvarwere vakura).